LEGEND® SAFELY AND EFECTIVELY TREATS NONINFECTIOUS SYNOVITIS.

Therapeutic objective

The primary objective of equine joint therapy should be to block the further release of inflammatory mediators while decreasing the effect of the mediators already released.

Legend delivers proven efficacy

In field studies, overall clinical improvement was judged to be excellent or good in 90% of the cases treated intravenously with Legend and 96 % of those treated intra-articularly with Legend.¹

Legend reduces joint inflammation and the resulting pain and lameness by decreasing the production and release of inflammatory mediators.

The interleukin-1-driven production and release of prostaglandin and also the protein count in synovial fluid is decreased for 45 days following I.V. injection, indicating a beneficial effect long after I.V. administration. ²

Legend is pure Hyaluronic Acid (HA)

HA stimulates endogenous HA production.	HA administration stimulates synoviocytes to produce endogenous high-molecular-weight HA.3
HA provides a physical barrier.	HA contributes to the steric exclusion of plasma components and leukocytes. 4
HA decreases the presence of inflammatory mediators.	HA decreases the interleukin-1-driven production and release of prostaglandin E2. PgE2 causes cartilage destruction.5 HA scavenges oxygen-derived free radicals.6

Legend is micro-filtered for purity

Derived naturally through a unique biofermentation process developed by Bayer, Legend is pure hyaluronic acid. After biofermentation, Legend is purified through a 12-step microfiltration process to remove impurities and foreign proteins. Foreign proteins increase the potential for joint flares.

Treat noninfectious synovitis with the proven performance of Legend:

The only FDA-approved joint therapy for both I.V. and I.A. administration, so you can choose the treatment to meet the horse's needs. Produced through biofermentation and purified though a 12-step microfiltration process to help reduce the presence of foreign proteins. Legend reduces joint inflammation and the resulting pain and lameness by decreasing the production and release of inflammatory mediators.² Legend is backed by extensive independent university studies and Bayer research. Up to three weekly I.V. doses of Legend will treat all affected fetlocks and carpi of the horse.

Click here to view the complete label and usage instructions.

Federal law restricts this drug to use by or on the order of a licensed veterinarian. For use only in horses. Do not use in horses intended for human consumption. Legend 4mL and Legend Multi dose 20mL are approved only for I.V. use. Legend 2mL is approved for I.V. and I.A. use. The intra-articular safety of Legend Multi Dose with benzyl alcohol has not been evaluated. The safety of Legend has not been evaluated in breeding stallions or in breeding, pregnant or lactating mares.

1. Freedom of Information Summary for Legend® (hyaluronate sodium) Injectable Solution. NADA 140-883.
2. Kawcak, CE; Frisbee, DD; Trotter, GW; McIlwraith, CW; Gillette, SM; Powers, BE; Walton, RM: Effects of intravenous administration of sodium hyaluronate on carpal joints in exercising horses after arthroscopic surgery and osteochondral fragmentation. AJVR 1997; 58(10): 1132-1140.
3. Smith, M.M.;Ghosh, P.: The synthesis of hyaluronic acid by human synovial fibroblasts is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int. 1987;7(3):113-22.
4. Balazs EA, Denlinger JL: Sodium hyaluronate and joint function. Equine Vet Sci 1985; 5: 217-228.
5. Lipiello L. Yamamoto K, Robinson D, et al: Involvement of prostaglandins from rheumatoid synovium in inhibition of articular cartilage metabolism. Arthritis Rheum. 1978; 21:909-917.
6. Sato H, Takahashi T, Ide H, et al. Antioxidant activity of synovial fluid, Hyaluronic acid and two subcomponents of hyaluronic acid. Arthritis Rheum 1988:31:63-71.